Appendix D

This Technical Report accompanies the Clinical management guidelines for the prevention of cervical cancer, developed by Cancer Council Australia.

It outlines the guideline development process and methodology, lists the clinical questions, provides all accompanying NHMRC Statement Forms, the detailed technical documentation for each question and the risk of bias assessment tools used to assess the included literature as a result of a systematic review.

Contents

Guideline Development Process

Figure 1. Overview review process

Clinical question list

NHMRC Evidence statements forms

• Evidence Statement question 1a
• Evidence Statement question 1b
• Evidence Statement question 2a

Systematic review, modelling and literature review reports

Management of oncogenic HPV test results - Oncogenic HPV types not 16/18

• Systematic review report question 1a
• Systematic review report question 1b
• Modelling report question 1a & 1b

Colposcopy - Normal colposcopic findings following LBC prediction of LSIL or HSIL

• Systematic review report question 2a
• Systematic review report question 2b
• Systematic review report question 2c
• General evidence summary table question 2b
• General evidence summary table question 2c

Colposcopy - Type 3 TZ (previously termed ‘unsatisfactory’) colposcopy following LBC prediction of LSIL or HSIL

• Systematic review report question 3a
• Systematic review report question 3b
• General evidence summary table question 3a
• General evidence summary table question 3b

Management of histologically confirmed low-grade squamous abnormalities

• Systematic review report question 4
• General evidence summary table question 4

Management of histologically confirmed high-grade squamous abnormalities

Treatment of HSIL

• Systematic review report question 6
• General evidence summary table question 6

Test of Cure after treatment for HSIL (CIN2/3)

• Systematic review report question 16
• General evidence summary table question 16

Management of glandular abnormalities

Investigation of cytological glandular abnormalities

• Systematic review report question 5a
• Systematic review report question 5b
• General evidence summary table question 5a
• General evidence summary table question 5b

Follow-up after excisional treatment for AIS

• Systematic review report question 7
• Systematic review report question 17
• General evidence summary table question 7
• General evidence summary table question 17

Screening in Aboriginal and Torres Strait Islander women

• Systematic review report question 12
• General evidence summary table question 12

Screening after total hysterectomy

• Literature summary and evidence report question 14

Screening in pregnancy

• Literature summary and evidence report question 13

Screening in women who have experienced early sexual activity or have been victims of sexual abuse

• Systematic review report question 10
• General evidence summary table question 10

Screening in immune-deficient women

• Systematic review report question 9
• General evidence summary table question 9

Screening in DES-exposed women

• Systematic review report question 11
• General evidence summary table question 11

Investigation of abnormal vaginal bleeding

• Systematic review report question 8
• General evidence summary table question 8

Cohort studies (risk factors) risk of bias assessment tool

• Cohort studies risk of bias assessment form
• Cohort studies risk of bias assessment help sheet